Iran has fired two waves of missiles into Israel overnight. Another set of strikes near Tel Aviv killed a 60-year-old woman, according to the Israeli emergency service Magen David Adom (MDA). A further 20 people have been injured in the same area, as well as 24 people in the Judean Foothills, a spokesperson for the MDA added.

Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

The Israeli attack, which comes amid an unprecedented exchange of strikes between Israel and Ansar Allah's Axis of Resistance coalition ally, Iran, was reported by a number of Israeli outlets as well as Saudi Arabia's Al-Hadath network.

Israel may be trying to take advantage of a window: Iran has reportedly not yet rebuilt air defences which were degraded by an Israeli attack in October, and Iran’s strongest proxy in the region, Hezbollah in Lebanon, has been significantly weakened by Israeli action.

Israel's attack on Iran raises questions like whether the US will get involved, how Iran will respond, and if a wider conflict may be triggered.

Israel launched strikes against Iran on June 12, throwing further negotiations over the regime's nuclear program into doubt.

Iran responded with an aerial attack involving about 100 drones, Israel said, but all of them were shot down before hitting their target. The U.S. did not provide any assistance or have any involvement in the Israeli strike, a U.S. official told ABC News.

Iran's foreign minister calls Israel's attacks on its nuclear programme a "declaration of war" as the IDF says it intercepted retaliatory drones launched by Tehran.